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Revisiting the Language of Glycoscience: Readers, Writers and Erasers in Carbohydrate Biochemistry
- Source :
- Chembiochem, Dedola, S, Rugen, M D, Young, R J & Field, R A 2020, ' Revisiting the Language of Glycoscience: Readers, Writers and Erasers in Carbohydrate Biochemistry ', CHEMBIOCHEM . https://doi.org/10.1002/cbic.201900377
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- The roles of carbohydrates in nature are many and varied. However, the lack of template encoding in glycoscience distances carbohydrate structure, and hence function, from gene sequence. This challenging situation is compounded by descriptors of carbohydrate structure and function that have tended to emphasise their complexity. Herein, we suggest that revising the language of glycoscience could make interdisciplinary discourse more accessible to all interested parties.<br />The lack of template‐encoding in glycoscience disconnects the “glyco code” from direct gene sequence control. Thus carbohydrate biosynthesis and glycan function depend upon a series of protein–carbohydrate interaction events. Descriptions of these events have tended to emphasise their complexity: here we suggest that revising the language of glycoscience could make interdisciplinary discourse more accessible to all parties.
- Subjects :
- Models, Molecular
Glycosylation
media_common.quotation_subject
Carbohydrates
Carbohydrate Biochemistry
010402 general chemistry
01 natural sciences
Biochemistry
glycosyl hydrolase
glycosyltransferase
Viewpoint
Manchester Institute of Biotechnology
Carbohydrate Conformation
Encoding (semiotics)
Function (engineering)
Carbohydrate composition
Molecular Biology
media_common
epigenetics
010405 organic chemistry
Organic Chemistry
glycoscience vocabulary
ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology
Linguistics
0104 chemical sciences
Viewpoints
Molecular Medicine
Gene sequence
Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 14397633 and 14394227
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Chembiochem
- Accession number :
- edsair.doi.dedup.....af3100ce88de787733c9213c1d6a5279