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IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment
- Source :
- OncoImmunology, Vol 8, Iss 1 (2019), Oncoimmunology
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis Group, 2019.
-
Abstract
- Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment. IL-33 is a local cytokine that can activate innate and adaptive immunity. We studied the effectiveness of local IL-33 delivery in the treatment of cancer that has metastasized to the peritoneal cavity. Direct peritoneal administration of IL-33 delayed the progression of metastatic peritoneal cancer. Prolongation in survival was not associated with a direct effect of IL-33 on tumor cells, but with major changes in the immune microenvironment of the tumor. IL-33 promoted a significant increase in the leukocyte compartment of the tumor immunoenvironment and an allergic cytokine profile. We observed a substantial increase in the number of activated CD4+ T-cells accompanied by peritoneal eosinophil infiltration, B-cell activation and activation of peritoneal macrophages which displayed tumoricidal capacity. Depletion of CD4+ cells, eosinophils or macrophages reduced the anti-tumor effects of IL-33 but none of these alone were sufficient to completely abrogate its positive benefit. In conclusion, local administration of IL-33 generates an allergic tumor environment resulting in a novel approach for treatment of metastatic peritoneal malignancies, such as advanced ovarian cancer.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
medicine.medical_treatment
Immunology
il-33
lcsh:RC254-282
03 medical and health sciences
Peritoneal cavity
0302 clinical medicine
Immune system
Immunology and Allergy
Medicine
tumor immunology
Original Research
business.industry
Immunotherapy
Eosinophil
medicine.disease
Acquired immune system
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
3. Good health
Interleukin 33
030104 developmental biology
medicine.anatomical_structure
Cytokine
ovarian cancer
Oncology
peritoneal cavity
030220 oncology & carcinogenesis
Cancer research
immunotherapy
business
Ovarian cancer
lcsh:RC581-607
Subjects
Details
- Language :
- English
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- OncoImmunology
- Accession number :
- edsair.doi.dedup.....af2ad07135d2cc7d46d5497cbc4d10d5