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Implications of anaemia and response to anaemia treatment on outcomes in patients with cirrhosis

Authors :
Jassin Rashidi-Alavijeh
Nargiz Nuruzade
Alexandra Frey
Eva-Maria Huessler
Anne Hörster
Amos Cornelius Zeller
Andreas Schütte
Hartmut Schmidt
Katharina Willuweit
Christian Markus Lange
Publication Year :
2023

Abstract

Background & Aims: Anaemia is frequently observed in patients with cirrhosis and was identified as a predictor of adverse outcomes, such as increased mortality and occurrence of acute-on-chronic liver failure. To date, the possible effects of iron supplementation on these adverse outcomes are not well described. We therefore aimed to assess the role of iron supplementation in patients with cirrhosis and its capability to improve prognosis. Methods: Laboratory diagnostics were performed in consecutive outpatients with cirrhosis admitted between July 2018 and December 2019 to the University Hospital Essen. Associations with transplant-free survival were assessed in regression models. Results: A total of 317 outpatients with cirrhosis were included, of whom 61 received a liver transplant (n = 19) or died (n = 42). In multivariate Cox regression analysis, male sex (hazard ratio [HR] = 3.33, 95% CI [1.59, 6.99], p = 0.001), model for end-stage liver disease score (HR = 1.19, 95% CI [1.11, 1.27], p

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....af28ba1a5e26c16a18995426700eb079