Back to Search
Start Over
A Possible Mechanism of Primary Ciliary Dyskinesia. A Case of a Segmental Defect in Ciliary Microtubules
- Source :
- Internal Medicine. 38:602-606
- Publication Year :
- 1999
- Publisher :
- Japanese Society of Internal Medicine, 1999.
-
Abstract
- We report here a 13-year-old woman with cough, sputum and fever. The patient had both chronic sinusitis and bronchitis. Chest X-ray and computed tomographic scan of the chest revealed mucous bronchial filling and bronchiectasia in bronchi of bilateral lower lobes, right middle lobe and left upper lobe. Aerosol inhalation scintigraphy with 99mTechnetium demonstrated delays of the discharged tracer. On the basis of these findings, primary ciliary dyskinesia was suggested. This was confirmed by the findings from nasal biopsy with transmission electron microscopy where all of the microtubules were segmentally defected near the basal body in the cilia. On the basis of these findings, we diagnosed the patient with primary ciliary dyskinesia which may be due, at least in part, to segmental defect of ciliary microtubules.
- Subjects :
- Pathology
medicine.medical_specialty
Adolescent
Microtubules
Internal Medicine
medicine
Humans
Basal body
Cilia
Sinusitis
Bronchitis
Radionuclide Imaging
Primary ciliary dyskinesia
business.industry
Cilium
Respiratory disease
Technetium
General Medicine
Anatomy
respiratory system
medicine.disease
Bronchiectasis
Microscopy, Electron
Dyskinesia
Sputum
Female
medicine.symptom
business
Ciliary Motility Disorders
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....af1f5fe992576a520e4eaa10191fe4c6