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A pathological study of the tongues of rabid dogs in the Philippines
- Source :
- Archives of Virology. 163:1615-1621
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- During rabies virus infections, the minor salivary glands are one of the important organs for virus replication and excretion into the oral cavity. However, details of pathological findings and viral antigen distribution in the minor salivary glands remain poorly understood. In this study, we conducted pathological tests on the tongues of 71 rabid dogs in the Philippines; the minor salivary glands (von Ebner's glands, lingual glands), circumvallate papilla, autonomic ganglia, and skeletal muscles were evaluated. Inflammatory changes were observed in the von Ebner's glands of 20/71 dogs, in the circumvallate papilla of 10/71, and in the tongue muscle of 1/71. Conversely, no morphological changes were observed in the lingual glands and autonomic ganglia. Viral antigens were detected via immunohistochemistry-based methods in the cytoplasm of the acinar epithelium in the von Ebner's glands of all 71 dogs. Virus particles were confirmed in the intercellular canaliculi and acinar lumen via electron microscopy. In the autonomic ganglia, viral antigens were detected in 67/71 rabid dogs. Viral antigens were detected in the taste buds of all 71 dogs, and were distributed mainly in type II and III taste bud cells. In tongue muscle fibers, viral antigens were detected in 11/71 dogs. No virus antigens were detected in lingual glands. These findings suggest that rabies virus descends in the tongue along the glossopharyngeal nerve after proliferation in the brain, and von Ebner's glands and taste buds are one of the portals of virus excretion into the saliva in rabid dogs.
- Subjects :
- Male
0301 basic medicine
Saliva
Pathology
medicine.medical_specialty
Rabies
040301 veterinary sciences
Philippines
Biology
Salivary Glands, Minor
medicine.disease_cause
Virus
0403 veterinary science
03 medical and health sciences
Dogs
Tongue
stomatognathic system
Virology
medicine
Animals
Muscle, Skeletal
Lingual papilla
Antigens, Viral
Ganglia, Autonomic
Rabies virus
Virion
04 agricultural and veterinary sciences
General Medicine
Taste Buds
Immunohistochemistry
Epithelium
Virus Shedding
030104 developmental biology
medicine.anatomical_structure
Glossopharyngeal nerve
Female
Subjects
Details
- ISSN :
- 14328798 and 03048608
- Volume :
- 163
- Database :
- OpenAIRE
- Journal :
- Archives of Virology
- Accession number :
- edsair.doi.dedup.....af161b51944a5f88d88336e66e2cec9c
- Full Text :
- https://doi.org/10.1007/s00705-018-3785-y