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Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity

Authors :
Alessandro, Maloberti
Nicola, Ughi
Davide Paolo, Bernasconi
Paola, Rebora
Iside, Cartella
Enzo, Grasso
Deborah, Lenoci
Francesca, Del Gaudio
Michela, Algeri
Sara, Scarpellini
Enrico, Perna
Alessandro, Verde
Caterina, Santolamazza
Francesco, Vicari
Maria, Frigerio
Antonia, Alberti
Maria Grazia, Valsecchi
Claudio, Rossetti
Oscar Massimiliano, Epis
Cristina, Giannattasio
On The Behalf Of The Niguarda Covid-Working Group
Maloberti, A
Ughi, N
Bernasconi, D
Rebora, P
Cartella, I
Grasso, E
Lenoci, D
Del Gaudio, F
Algeri, M
Scarpellini, S
Perna, E
Verde, A
Santolamazza, C
Vicari, F
Frigerio, M
Alberti, A
Valsecchi, M
Rossetti, C
Epis, O
Giannattasio, C
Source :
Journal of Clinical Medicine, Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5590, Journal of Clinical Medicine, Vol 10, Iss 5590, p 5590 (2021)
Publication Year :
2021

Abstract

The most common arrhythmia associated with COronaVIrus-related Disease (COVID) infection is sinus tachycardia. It is not known if high Heart Rate (HR) in COVID is simply a marker of higher systemic response to sepsis or if its persistence could be related to a long-term autonomic dysfunction. The aim of our work is to assess the prevalence of elevated HR at discharge in patients hospitalized for COVID-19 and to evaluate the variables associated with it. We enrolled 697 cases of SARS-CoV2 infection admitted in our hospital after February 21 and discharged within 23 July 2020. We collected data on clinical history, vital signs, laboratory tests and pharmacological treatment. Severe disease was defined as the need for Intensive Care Unit (ICU) admission and/or mechanical ventilation. Median age was 59 years (first-third quartile 49, 74), and male was the prevalent gender (60.1%). 84.6% of the subjects showed a SARS-CoV-2 related pneumonia, and 13.2% resulted in a severe disease. Mean HR at admission was 90 ± 18 bpm with a mean decrease of 10 bpm to discharge. Only 5.5% of subjects presented HR > 100 bpm at discharge. Significant predictors of discharge HR at multiple linear model were admission HR (mean increase = β = 0.17 per bpm, 95% CI 0.11; 0.22, p < 0.001), haemoglobin (β = −0.64 per g/dL, 95% CI −1.19; −0.09, p = 0.023) and severe disease (β = 8.42, 95% CI 5.39; 11.45, p < 0.001). High HR at discharge in COVID-19 patients is not such a frequent consequence, but when it occurs it seems strongly related to a severe course of the disease.

Details

ISSN :
20770383
Volume :
10
Issue :
23
Database :
OpenAIRE
Journal :
Journal of clinical medicine
Accession number :
edsair.doi.dedup.....af14309a68e0f02c1b861265d68bd59f