Back to Search
Start Over
The Gross Appearance of a NUT Midline Carcinoma
- Source :
- International journal of surgical pathology. 24(1)
- Publication Year :
- 2015
-
Abstract
- The NUT midline carcinoma (NMC) is a recently described and highly aggressive tumor that usually involves the head and neck and anterior mediastinum. Most patients with NMC present with metastases and are often treated with neoadjuvant chemotherapy and/or radiation therapy. As a consequence, surgical specimens are often piecemeal excisions demonstrating treatment effect. In this report, we provide what is to the best of our knowledge the first complete gross description of NMC resected in toto and without prior treatment. The patient in this case underwent a pneumonectomy for a lung mass with curative intent. On gross examination, the tumor was found to be arising from the mediastinum with a smooth border, and demonstrated only minimal invasion of the surrounding structures. However, lymphovascular invasion was present throughout and there was extensive involvement of surrounding lymph nodes. The gross appearance of the tumor in this case reaffirms that NMC is an aggressive malignancy that usually metastasizes before it invades locally.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Lymphovascular invasion
medicine.medical_treatment
Malignancy
Mediastinal Neoplasms
Pathology and Forensic Medicine
Gross examination
03 medical and health sciences
Pneumonectomy
0302 clinical medicine
Fatal Outcome
medicine
Humans
NUT midline carcinoma
Gene Rearrangement
Oncogene Proteins
Lung
business.industry
Carcinoma
Mediastinum
Nuclear Proteins
medicine.disease
Surgery
Neoplasm Proteins
Radiation therapy
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Anatomy
business
Subjects
Details
- ISSN :
- 19402465
- Volume :
- 24
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of surgical pathology
- Accession number :
- edsair.doi.dedup.....af0597045812c50d964e7240f2a9b8c7