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Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes
- Source :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2020
- Publisher :
- Georg Thieme Verlag KG, 2020.
-
Abstract
- Made available in DSpace on 2021-06-25T10:47:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Casearia sylvestris is an outstanding representative of the Casearia genus. This representability comes from its distinctive chemical profile and pharmacological properties. This species is widespread from North to South America, occurring in all Brazilian biomes. Based on their morphology, 2 varieties are recognized: C. sylvestris var. sylvestris and C. sylvestris var. lingua. Despite the existence of data about their chemical composition, a deeper understanding of the specialized metabolism correlation and variation in respect to environmental factors and its repercussion over their biological activities was still pending. In this study, an UHPLC-DAD-based metabolomics approach was employed for the investigation of the chemical variation of 12 C. sylvestris populations sampled across 4? Brazilian biomes and ecotones. The correlation between infraspecific chemical variability and the cytotoxic and antioxidant activities was achieved by multivariate data analysis. The analyses showed that C. sylvestris var. lingua prevailed at Cerrado areas, and it was correlated with lower cytotoxic activity and high level of glycosylated flavonoids. Among them, narcissin and isorhamnetin-3- O-α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside showed good correlation with the antioxidant activity. Conversely, C. sylvestris var. sylvestris prevailed at the Atlantic Forest areas, and it was associated with high cytotoxic activity and high content of clerodane diterpenoids. Different casearins showed good correlation (R 2= 0.3?-?0.70) with the cytotoxic activity. These findings highlighted the great complexity among different C. sylvestris populations, their chemical profile, and the related biological activities. Consequently, it can certainly influence the medicinal properties, as well as the quality and efficacy, of C. sylvestris phytomedicines. Institute of Chemistry Department of Biochemistry and Organic Chemistry São Paulo State University (UNESP), CEP 14800-060, Rua Prof. Francisco Degni 55 Natural Products Laboratory Institute of Biology Leiden University Natl. Inst. of Alternative Technol. for Detection Toxicological Assess. Removal of Micropollutants and Radioactive Substances Araraquara Agronomic Institute of Campinas Herbarium IAC Department of Biophysics and Physiology Laboratory of Experimental Cancerology Federal University of Piauí Department of Physiology and Pharmacology Faculty of Medicine Federal University of Ceará Institute of Chemistry Department of Biochemistry and Organic Chemistry São Paulo State University (UNESP), CEP 14800-060, Rua Prof. Francisco Degni 55
- Subjects :
- 0106 biological sciences
multivariate data analysis
Salicaceae
Casearia
Biome
Pharmaceutical Science
01 natural sciences
Diterpenes, Clerodane
Analytical Chemistry
03 medical and health sciences
Genus
Casearia sylvestris
Drug Discovery
Botany
plant ecophysiology
Ecosystem
030304 developmental biology
Pharmacology
0303 health sciences
biology
Plant Extracts
Organic Chemistry
biological activities
Biological activity
Ecotone
biology.organism_classification
metabolomics
clerodane diterpenoids
glycosylated flavonoids
Complementary and alternative medicine
Molecular Medicine
Brazil
010606 plant biology & botany
Subjects
Details
- ISSN :
- 14390221 and 00320943
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Planta Medica
- Accession number :
- edsair.doi.dedup.....aeffbfa1de571dcd17a7605534a293e5