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Prophylactic strategies for acute hemolysis secondary to plasma-incompatible platelet transfusions: correlation between qualitative hemolysin test and isohemagglutinin titration
- Source :
- Revista Brasileira de Hematologia e Hemoterapia, Revista Brasileira de Hematologia e Hemoterapia, Vol 37, Iss 4, Pp 217-222 (2015), Revista Brasileira de Hematologia e Hemoterapia v.37 n.4 2015, Revista brasileira de hematologia e hemoterapia, Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC), instacron:ABHHTC, Revista Brasileira de Hematologia e Hemoterapia, Volume: 37, Issue: 4, Pages: 217-222, Published: AUG 2015
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- OBJECTIVE: Brazilian legislation has recently suggested the use of the qualitative hemolysin test instead of isohemagglutinin titers as prophylaxis for acute hemolysis related to plasma-incompatible platelet transfusions. The efficacy of this test in preventing hemolytic reactions has never been evaluated while isohemagglutinin titers have been extensively studied. The main objective of this study was to evaluate the correlation between the results of these two tests. The impact of each type of prophylaxis on the platelet inventory management and the ability of the qualitative hemolysin test to prevent red cell sensitization after the transfusion of incompatible units were also studied. METHODS: A total of 246 donor blood samples were evaluated using both isohemagglutinin titers and the qualitative hemolysin test, and the results were statistically compared. Subsequently, 600 platelet units were tested using the hemolysin assay and the percentage of units unsuitable for transfusion was compared to historical data using isohemagglutinin titers (cut-off: 100). Moreover, ten patients who received units with minor ABO incompatibilities that were negative for hemolysis according to the qualitative hemolysin test were evaluated regarding the development of hemolysis and red cell sensitization (anti-A or anti-B). RESULTS: Isohemagglutinin titration and the results of qualitative hemolysin test did not correlate. The routine implementation of the qualitative hemolysin test significantly increased the percentage of platelet units found unsuitable for transfusions (15-65%; p-value
- Subjects :
- Blood group incompatibility
Red Cell
ABO blood-group system
lcsh:RC633-647.5
business.industry
Hemolysin
lcsh:Diseases of the blood and blood-forming organs
Hematology
Hemolysin Proteins
medicine.disease
Hemolysin proteins
Hemolysis
Isohemagglutinin
Platelet transfusion
ABO blood group system
Immunology
medicine
Platelet
Original Article
business
Subjects
Details
- ISSN :
- 15168484
- Volume :
- 37
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Revista Brasileira de Hematologia e Hemoterapia
- Accession number :
- edsair.doi.dedup.....aefbcfde4ff2a80e177d7e6cbb38d315
- Full Text :
- https://doi.org/10.1016/j.bjhh.2015.05.001