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Novel Biomarkers for Evaluation of Endothelial Dysfunction
- Source :
- Angiology. 71(5)
- Publication Year :
- 2020
-
Abstract
- Endothelial dysfunction is one of the earliest indicators of cardiovascular (CV) dysfunction, and its evaluation would be of considerable importance to stratify CV risk of many diseases and to assess the efficacy of atheroprotective treatments. Flow-mediated dilation is the most widely used method to study endothelial function. However, it is operator-dependent and can be influenced by physiological variations. Circulating biomarkers are a promising alternative. Due to the complexity of endothelial function, many of the biomarkers studied do not provide consistent information about the endothelium when measured alone. New circulating markers are being explored and some of them are thought to be suitable for the clinical setting. In this review, we focus on novel biomarkers of endothelial dysfunction, particularly endothelial microparticles, endocan, and endoglin, and discuss whether they fulfill the criteria to be applied in clinical practice.
- Subjects :
- Endothelium
030204 cardiovascular system & hematology
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Cell-Derived Microparticles
Medicine
Humans
Endothelial dysfunction
030304 developmental biology
0303 health sciences
business.industry
Endoglin
medicine.disease
Neoplasm Proteins
Clinical Practice
Circulating biomarkers
medicine.anatomical_structure
Cardiovascular Diseases
Biomarker (medicine)
Proteoglycans
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 19401574
- Volume :
- 71
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....aefa3e6ea224f41a7ccb51a254ed08a0