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Ovarian Mucinous Carcinoma in a Pediatric Patient With Maroteaux-Lamy Syndrome
- Source :
- Journal of Pediatric Hematology/Oncology. 43:e1128-e1131
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Mucopolysaccharidoses (MPS) are autosomal recessive lysosomal storage disorder (LSD). Mucinous ovarian cancer is a rare tumor and seldom encounters among adolescents. Here we describe an adolescent female with MPS type VI diagnosed with mucinous ovarian cancer. To our knowledge, this is the first case report of ovarian mucinous carcinoma in a patient with MPS. The association between MPS and cancer has never been described so far, but some LSD are known to have an increased risk of malignancies. The pathogenetic link between LSD and cancer is not well understood. Several potential mechanisms have been proposed for pathogenesis, which include chronic inflammation, abnormal function of activated macrophages, and genetic modifiers. Further studies are required, to understand the role of LSD in cancer.
- Subjects :
- Oncology
medicine.medical_specialty
Adolescent
Inflammation
Pathogenesis
Internal medicine
medicine
Humans
Ovarian Mucinous Carcinoma
Ovarian Neoplasms
Mucopolysaccharidosis VI
business.industry
Cancer
Hematology
Prognosis
medicine.disease
Adenocarcinoma, Mucinous
Maroteaux–Lamy syndrome
Pediatric patient
Increased risk
Pediatrics, Perinatology and Child Health
Female
medicine.symptom
business
Ovarian cancer
Subjects
Details
- ISSN :
- 10774114
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Hematology/Oncology
- Accession number :
- edsair.doi.dedup.....aef6e3730bc6818b18e3a96a6a203502