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Qualitative review and quantitative effect size meta-analyses in brain regions identified by cue-reactivity addiction studies
- Source :
- Neuropsychology. 33(3)
- Publication Year :
- 2019
-
Abstract
- Objective Various brain regions have been identified as involved in addictions, yet inconsistencies remain regarding the primary regions that may underlie addictive behaviors. To address this, we conducted a meta-analysis investigating cue-reactivity functional MRI studies for different addictions. Method We explored 8 different addiction-related brain regions in 27 studies (29 samples) using homogeneity tests of effect sizes. Results An initial qualitative review failed to identify consistent activations in any brain region. We subsequently explored possible moderators related to either the addiction, participants, or study design, and found addiction type to be a relevant moderator, suggesting that different addictions may not necessarily involve the same brain regions. Successive quantitative analyses found that internet gaming addiction and heroin dependence modulated neural activation in the right dorsolateral prefrontal cortex and heroin dependence further in the right orbitofrontal cortex. Our analyses also demonstrated the expected mean effect sizes in each region when conducting cue-reactivity experiments on addictions. Conclusions It appears that distinct addiction types may manifest differently in the brain and may moderate cue reactivity to a greater extent than previously suggested factors. This study underscores the need for additional research comparing the neural mechanisms underlying different addiction types. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
- Subjects :
- media_common.quotation_subject
Brain mapping
050105 experimental psychology
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
media_common
Brain Mapping
medicine.diagnostic_test
Addiction
05 social sciences
Brain
Moderation
Magnetic Resonance Imaging
Dorsolateral prefrontal cortex
Behavior, Addictive
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Cue reactivity
Meta-analysis
Orbitofrontal cortex
Cues
Psychology
Functional magnetic resonance imaging
Clinical psychology
Subjects
Details
- ISSN :
- 19311559
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neuropsychology
- Accession number :
- edsair.doi.dedup.....aee68f229347af0b3136f9cc8853f87c