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Cellular Senescence: Defining a Path Forward
- Source :
- Cell, Cell, Elsevier, 2019, 179 (4), pp.813-827. ⟨10.1016/j.cell.2019.10.005⟩, Spiral-Imperial College Digital Repository, Hyper Article en Ligne, Apollo, Cell, 2019, 179 (4), pp.813-827. ⟨10.1016/j.cell.2019.10.005⟩, Gorgoulis, V, Adams, P D, Alimonti, A, Bennett, D C, Bischof, O, Bishop, C, Campisi, J, Collado, M, Evangelou, K, Ferbeyre, G, Gil, J, Hara, E, Krizhanovsky, V, Jurk, D, Maier, A B, Narita, M, Niedernhofer, L, Passos, J F, Robbins, P D, Schmitt, C A, Sedivy, J, Vougas, K, von Zglinicki, T, Zhou, D, Serrano, M & Demaria, M 2019, ' Cellular Senescence : Defining a Path Forward ', Cell, vol. 179, no. 4, pp. 813-827 . https://doi.org/10.1016/j.cell.2019.10.005
- Publication Year :
- 2019
-
Abstract
- International audience; Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
- Subjects :
- Senescence
EXPRESSION
Aging
Cell cycle checkpoint
[SDV]Life Sciences [q-bio]
Cell
DNA-DAMAGE RESPONSE
[SDV.CAN]Life Sciences [q-bio]/Cancer
Computational biology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Mitochondrion
Biology
General Biochemistry, Genetics and Molecular Biology
CHROMATIN LANDSCAPE
03 medical and health sciences
0302 clinical medicine
MITOCHONDRIA
ONCOGENE-INDUCED SENESCENCE
medicine
Humans
OXIDATIVE STRESS
Senolytic
Cellular Senescence
11 Medical and Health Sciences
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Regulation of gene expression
0303 health sciences
P53
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
Genetic Diseases, Inborn
DARK SIDE
Cell Cycle Checkpoints
06 Biological Sciences
CANCER
Chromatin
medicine.anatomical_structure
Gene Expression Regulation
CELLS
Developmental biology
030217 neurology & neurosurgery
Biomarkers
Developmental Biology
Subjects
Details
- ISSN :
- 00928674 and 10974172
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....aee3d348be3cde11eb370d32f2773fe1
- Full Text :
- https://doi.org/10.1016/j.cell.2019.10.005