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Circulating lipidomic alterations in obese and non-obese subjects with non-alcoholic fatty liver disease
- Source :
- Alimentary Pharmacology & Therapeutics.
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND Non-alcoholic fatty liver disease (NAFLD) affects obese and non-obese individuals. However, mechanisms underlying non-obese non-alcoholic steatohepatitis (NASH) remain unclear. AIMS To attempt to identify metabolic perturbations associated with non-obese and obese NAFLD using a lipidomics approach. METHODS A cross-sectional analysis of 361 subjects with biopsy-proven NAFLD (157 NAFL and 138 NASH) and healthy controls (n = 66) was performed. Individuals were categorised as obese or non-obese based on the Asian cut-off for body mass index. Circulating lipidomic profiling of sera was performed based on the histological severity of NAFLD. Circulating lipidomic alterations were validated with an independent validation set (154 NAFLD subjects [93 NAFL and 61 NASH] and 21 healthy controls). RESULTS Saturated sphingomyelin (SM) species were significantly associated with visceral adiposity in non-obese NAFLD (SM d38:0; P
- Subjects :
- Adult
Male
medicine.medical_specialty
Adipose tissue
Disease
digestive system
Gastroenterology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Non-alcoholic Fatty Liver Disease
Internal medicine
Lipidomics
Humans
Medicine
Pharmacology (medical)
Obesity
030212 general & internal medicine
Aged
Hepatology
business.industry
Fatty liver
Area under the curve
nutritional and metabolic diseases
Middle Aged
medicine.disease
Lipids
digestive system diseases
Cross-Sectional Studies
Case-Control Studies
Female
030211 gastroenterology & hepatology
Insulin Resistance
Steatohepatitis
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 02692813
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....aedc71d0ebe5a065db71c95d6fe0bfeb