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Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats
- Source :
- Journal of Clinical Biochemistry and Nutrition
- Publication Year :
- 2009
-
Abstract
- Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin and adiponectin levels, serum and hepatic lipid levels, and parameters of bone loss in streptozotocin (STZ)-induced marginal type 1 diabetic rats. Weanling male rats were randomly assigned to experimental 3 groups: a control (C) group, a STZ induced marginal type 1 diabetes (S) group, and a diabetes and hesperidin group, and fed their respective diets for 4 weeks. STZ injection increased blood glucose in rats, but the increase was marginal. Serum and hepatic lipids, serum adiponectin and insulin levels were significantly changed by STZ injection. Dietary hesperidin (10 g/kg diet) decreased blood glucose by altering the activity of glucose-regulating enzymes, and normalized the lipids and adiponectin levels, but did not change bone parameters in the marginal type 1 diabetic rats. Hesperidin showed both hypoglycemic and hypolipidemic effects but did not affect bone tissue and bone metabolic makers in STZ-injected marginal diabetic weanling rats without any body weight loss due to STZ injection.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
type 1 diabetes
medicine.medical_treatment
Clinical Biochemistry
Medicine (miscellaneous)
Blood sugar
lipids
Hesperidin
chemistry.chemical_compound
Blood serum
hesperidin
Internal medicine
Diabetes mellitus
medicine
storeptozotocin
Type 1 diabetes
Nutrition and Dietetics
Adiponectin
business.industry
Insulin
nutritional and metabolic diseases
Streptozotocin
medicine.disease
glucose regulating enzymes
Endocrinology
chemistry
Original Article
business
medicine.drug
Subjects
Details
- ISSN :
- 18805086
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of clinical biochemistry and nutrition
- Accession number :
- edsair.doi.dedup.....aed00d6fb8b17561ecd4f75967c1b2b6