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High Rates of Genetic Diagnosis in Psychiatric Patients with and without Neurodevelopmental Disorders: Toward Improved Genetic Diagnosis in Psychiatric Populations
- Source :
- Can J Psychiatry
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Objective:There is a paucity of literature on genetic diagnosis in psychiatric populations, particularly the vulnerable population of patients with concomitant neurodevelopmental disorder (NDD). In this cross-sectional study, we investigated the genetic diagnostic rate in 151 adult psychiatric patients from two centers in Ontario, Canada, including a large subset (73.5%) with concurrent NDD, and performed phenotypic analysis to determine the strongest predictors for the presence of a genetic diagnosis.Method:Patients 16 years of age or older and affected with a psychiatric disorder plus at least one of NDD, neurological disorder, congenital anomaly, dysmorphic features, or family history of NDD were recruited through the genetics clinics between 2012 and 2016. Patients underwent genetic assessment and testing according to clinical standards. Chi-squared test was used for phenotypic comparisons. Multivariate logistic regression analysis was performed to determine which phenotypic features were predictive of genetic diagnosis types.Results:Overall, 45.7% of patients in the total cohort were diagnosed with genetic disorders with the vast majority of diagnoses (89.9%) comprising single gene and chromosomal disorders. There were management and treatment implications for almost two-thirds (63.8%) of diagnosed patients. Presence of a single gene disorder or chromosomal diagnosis was predicted by differing combinations of neurological, NDD, and psychiatric phenotypes.Conclusion:The results of this study highlight the frequency and impact of genetic diagnosis in psychiatric populations, particularly those with concomitant NDD. Genetic assessment should be considered in psychiatric patients, particularly those with multiple brain phenotypes (psychiatric, neurodevelopmental, neurological).
- Subjects :
- Adult
Male
medicine.medical_specialty
03 medical and health sciences
0302 clinical medicine
Neurodevelopmental disorder
medicine
Humans
Vulnerable population
Genetic Predisposition to Disease
Psychiatry
Original Research
030304 developmental biology
Ontario
High rate
0303 health sciences
Adult psychiatry
business.industry
Mental Disorders
Middle Aged
medicine.disease
3. Good health
Psychiatry and Mental health
Cross-Sectional Studies
Phenotype
Diagnosis, Dual (Psychiatry)
Neurodevelopmental Disorders
Concomitant
Dual diagnosis
Female
business
Genetic diagnosis
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14970015 and 07067437
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- The Canadian Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....aec1b74c005255477cade2f0a4060b15