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Community-based sero-prevalence of chikungunya and yellow fever in the South Omo Valley of Southern Ethiopia
- Source :
- PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008549 (2020), PLoS Neglected Tropical Diseases
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Background Chikungunya (CHIK) and yellow fever (YF) are becoming major public health threats in East African countries including Ethiopia. In Ethiopia, there is no reliable information about the epidemiology of CHIK. This study aimed to assess a community-based sero-prevalence of CHIK and YF in the South Omo Valley, an endemic area for YF. Methods Between February and June 2018, blood samples were collected from study participants and screened for IgG antibody against CHIK virus (CHIKV) and YF virus (YFV) infections using ELISA. Data were computerized using Epi Data Software v.3.1 and analyzed using SPSS. Results A total of 360 participants (51.7% males, age range from 6 to 80, mean age ± SD = 31.95 ± 14.05 years) participated in this study. The overall sero-prevalence of IgG antibody was 43.6% (157/360) against CHIKV, while it was 49.5% (155/313) against YFV. Out of 155 samples which were positive for IgG antibody to YFV, 93 (60.0%) were positive for IgG antibody to CHIKV. Out of 158 samples which were negative for IgG antibody to YFV, 64(40.5%) were positive for IgG antibody to CHIKV. There was a significant positive correlation between IgG antibodies to CHIKV and YFV (sr = 0.82; P<br />Author summary Mosquito-borne viral diseases including yellow fever and chikungunya are becoming major public health problem in Africa. Community-based sero-epidemiological studies of mosquito-borne viral infections are important to known the occurrence of these diseases and to design appropriate prevention and control strategies. In this study, we assessed the sero-prevalence of IgG antibody against Chikungunya virus and Yellow fever virus in 360 study participants and associated risk factors among the community members of South Omo, Southern Ethiopia. Our study showed a sero-prevalence of IgG antibody; 43.6%, (157 out of 360) to Chikungunya virus, and 49.5% (155 out of 313) against Yellow fever virus in the study participants.Further studies on active case detection of chikungunya and raising awareness, advocating policies to mitigate the risk of arboviral infections have paramount importance in the present study area.
- Subjects :
- 0301 basic medicine
RNA viruses
Male
Viral Diseases
Cross-sectional study
Physiology
RC955-962
medicine.disease_cause
Pathology and Laboratory Medicine
Antibodies, Viral
Biochemistry
Dengue fever
Geographical Locations
0302 clinical medicine
Medical Conditions
Residence Characteristics
Seroepidemiologic Studies
Immune Physiology
Arctic medicine. Tropical medicine
Epidemiology
Medicine and Health Sciences
Public and Occupational Health
Chikungunya
Enzyme-Linked Immunoassays
Child
Aged, 80 and over
Vaccines
Immune System Proteins
Chikungunya Virus
biology
Yellow fever
virus diseases
Middle Aged
Vaccination and Immunization
Infectious Diseases
Medical Microbiology
Arboviral Infections
Viral Pathogens
Viruses
Female
Antibody
Pathogens
Yellow fever virus
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Infectious Disease Control
Adolescent
Alphaviruses
030231 tropical medicine
Immunology
Research and Analysis Methods
Microbiology
Virus
Antibodies
Togaviruses
03 medical and health sciences
Young Adult
Yellow Fever
medicine
Humans
Immunoassays
Microbial Pathogens
Aged
business.industry
Public Health, Environmental and Occupational Health
Organisms
Outbreak
Biology and Life Sciences
Proteins
Chikungunya Infection
medicine.disease
Tropical Diseases
Virology
030104 developmental biology
Cross-Sectional Studies
People and Places
Africa
biology.protein
Immunologic Techniques
Chikungunya Fever
Preventive Medicine
Ethiopia
business
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 14
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....aeb91e76a0f079350eb152ce22699a57