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Evaluation of Cryoglobulins
- Source :
- Archives of Pathology & Laboratory Medicine. 123:119-125
- Publication Year :
- 1999
- Publisher :
- Archives of Pathology and Laboratory Medicine, 1999.
-
Abstract
- Cryoglobulins are immunoglobulins that precipitate as serum is cooled below core body temperatures. A cryoglobulin screen is the observation of a serum specimen collected and separated while warm for cryoprecipitation over a period of up to 7 days. Values of the screening may be reported as a cryocrit, which is the volume percent of the precipitate compared with the total volume of serum. Further proof that the precipitate is indeed a cryoglobulin can be obtained by demonstrating resolubilization with warming and immunochemical analysis by immunofixation. Detailed characterization of cryoglobulins may also require rigorous washing of the precipitate, quantitation of total protein and immunoglobulins, and evaluation of serum for monoclonal gammopathy, rheumatoid factor activity, evidence of complement activation, and presence of hepatitis C virus seroreactivity or hepatitis C virus RNA. The single most important variable confounding standardization of cryoglobulin testing is the frequently improper separation of warm serum from other blood elements prior to screening and characterization.
- Subjects :
- Immunofixation
biology
business.industry
Hepatitis C virus
Paraproteinemias
Immunoglobulins
General Medicine
Laboratories, Hospital
medicine.disease
medicine.disease_cause
Cryoglobulinemia
Cryoglobulins
Pathology and Forensic Medicine
Complement system
Medical Laboratory Technology
Cryoglobulin
Immunology
biology.protein
Chemical Precipitation
Humans
Medicine
Rheumatoid factor
Antibody
business
Subjects
Details
- ISSN :
- 15432165 and 00039985
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- Archives of Pathology & Laboratory Medicine
- Accession number :
- edsair.doi.dedup.....aea1b671c24bbacfe61b2d9e6b59bfa8