Back to Search
Start Over
Effect of Preoperative Inflammatory Status and Comorbidities on Pain Resolution and Persistent Postsurgical Pain after Inguinal Hernia Repair
- Source :
- Mediators of Inflammation, Vol 2016 (2016), Mediators of Inflammation, Mediators of Inflammation, Vol. 2016, no.5830347, p. [1-7] (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Poor acute pain control and inflammation are important risk factors for Persistent Postsurgical Pain (PPSP). The aim of the study is to investigate, in the context of a prospective cohort of patients undergoing hernia repair, potential risk factors for PPSP. Data about BMI, anxious-depressive disorders, neutrophil-tolymphocyte ratio (NLR), proinflammatory medical comorbidities were collected. An analysis for correlation between comorbidities and PPSP was performed in those patients experiencing chronic pain at 3 months after surgery. Tramadol resulted less effective in pain at movement in patients with a proinflammatory status. Preoperative hypertension and NLR > 4 were correlated with PPSP intensity. Regional anesthesia was significantly protective on PPSP when associated with ketorolac. Patients with pain at 1 month were significantly more prone to develop PPSP at 3 months. NSAIDs or weak opioids are equally effective on acute pain and on PPSP development after IHR, but Ketorolac has better profile in patients with inflammatory background or undergoing regional anesthesia. Drug choice should be based on their potential side effects, patient’s profile (comorbidities, preoperative inflammation, and hypertension), and type of anesthesia. Close monitoring is necessary to early detect pain conditions more prone to progress to a chronic syndrome.
- Subjects :
- Adult
Male
Article Subject
medicine.medical_treatment
Immunology
Hernia, Inguinal
Context (language use)
Comorbidity
03 medical and health sciences
0302 clinical medicine
030202 anesthesiology
medicine
lcsh:Pathology
Humans
Hernia
Longitudinal Studies
Intraoperative Complications
Prospective cohort study
Tramadol
Acetaminophen
Aged
Pain Measurement
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Chronic pain
Cell Biology
Middle Aged
medicine.disease
Hernia repair
Analgesics, Opioid
Ketorolac
Inguinal hernia
Anesthesia
Female
Chronic Pain
business
030217 neurology & neurosurgery
Research Article
medicine.drug
lcsh:RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 09629351
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation
- Accession number :
- edsair.doi.dedup.....ae90dd4827008f453bccd69748bf0307
- Full Text :
- https://doi.org/10.1155/2016/5830347