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Effects of Vitamin K2 (Menatetrenone) on Calcium Balance in Ovariectomized Rats
- Source :
- Japanese Journal of Pharmacology. 88:55-61
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Vitamin K2 (menatetrenone) has been used for the treatment of osteoporosis in Japan. We investigated the effects of ovariectomy (OVX) and vitamin K2 on the calcium (Ca) balance in 20-week-old female Fischer rats. Vitamin K2 (31 mg/kg per day) was given to animals as a dietary supplement. At weeks 4 and 8 after OVX, a Ca balance study was performed for 5 days. The intestinal Ca transport was determined using the everted gut-sac technique at week 9. The Ca balance was poorer in the OVX-control group than in the sham-control group at weeks 4 and 8 after OVX. The Ca balance improved significantly in the vitamin K2 groups as compared with the sham- and OVX-control groups. The intestinal Ca transport decreased due to OVX and was higher in the vitamin K2 administration groups than in the sham- and OVX-control groups, but not to a significant extent. The bone mineral density in the femoral metaphysis as well as the cortical area and cortical thickness in the femoral diaphysis in the OVX-control group were lower than in the sham-control group. The administration of vitamin K2 significantly inhibited an OVX-induced decrease in cortical area and cortical thickness in the femur. These findings suggest that the poor Ca balance observed in ovariectomized rats may be improved by vitamin K2; vitamin K2 may be involved in preventing bone loss in vivo.
- Subjects :
- medicine.medical_specialty
Ovariectomy
Osteoporosis
chemistry.chemical_element
Calcium
Feces
Bone Density
Internal medicine
medicine
Menatetrenone
Animals
Homeostasis
Femur
Intestinal Mucosa
Pharmacology
Calcium metabolism
Bone mineral
Chemistry
Body Weight
Uterus
Vitamin K2
Biological Transport
Vitamin K 2
Organ Size
medicine.disease
Rats, Inbred F344
Rats
Intestines
surgical procedures, operative
Endocrinology
Ovariectomized rat
Female
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00215198
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....ae805dc3cf5fd385bbc3c4c903795701