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Screening, Characterization and Evaluation of Mangiferin Polymorphs
- Source :
- Natural Products and Bioprospecting, Vol 10, Iss 4, Pp 187-200 (2020), Natural Products and Bioprospecting
- Publication Year :
- 2020
- Publisher :
- SpringerOpen, 2020.
-
Abstract
- Abstract Mangiferin is a compound with many pharmacological activities and exists in many natural products. Anhydrous and hydrate of mangiferin have been reported separately in two literatures, but the polymorphism of this compound has not been realized until this paper. In this study, polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never reported. Several solid state characterization methods, such as powder X-ray diffraction, differential scanning calorimetry and thermogravimetry, are used to identify and characterize all of mangiferin forms. The comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and hydrate. Furthermore, the studies on stability, transformation and solubility have been undertaken, the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals. Graphic Abstract
- Subjects :
- Crystallographic data
Plant Science
Toxicology
Biochemistry
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Differential scanning calorimetry
Computational chemistry
Solubility
Mangiferin
Pharmacology
0303 health sciences
Chemistry
030302 biochemistry & molecular biology
Organic Chemistry
Polymorph screening
Botany
Characterize
Thermogravimetry
Polymorphism (materials science)
030220 oncology & carcinogenesis
QK1-989
Anhydrous
Original Article
Hydrate
Stability
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 21922209 and 21922195
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Natural Products and Bioprospecting
- Accession number :
- edsair.doi.dedup.....ae73da172d452102156b68f2c4c04ed0