Back to Search
Start Over
Sequential karyotyping in Burkitt lymphoma reveals a linear clonal evolution with increase in karyotype complexity and a high frequency of recurrent secondary aberrations
- Source :
- British Journal of Haematology, 170(6), 814-825. Wiley
- Publication Year :
- 2015
-
Abstract
- Typical Burkitt lymphoma is characterized by an IG-MYC translocation and overall low genomic complexity. Clinically, Burkitt lymphoma has a favourable prognosis with very few relapses. However, the few patients experiencing disease progression and/or relapse have a dismal outcome. Here we report cytogenetic findings of seven cases of Burkitt lymphoma in which sequential karyotyping was performed at time of diagnosis and/or disease progression/relapse(s). After case selection, karyotype re-review and additional molecular analyses were performed in six paediatric cases, treated in Berlin-Frankfurt-Munster-Non-Hodgkin lymphoma study group trials, and one additional adult patient. Moreover, we analysed 18 cases of Burkitt lymphoma from the Mitelman database in which sequential karyotyping was performed. Our findings show secondary karyotypes to have a significant increase in load of cytogenetic aberrations with a mean number of 2, 5 and 8 aberrations for primary, secondary and third investigations. Importantly, this increase in karyotype complexity seemed to result from recurrent secondary chromosomal changes involving mainly trisomy 21, gains of 1q and 7q, losses of 6q, 11q, 13q, and 17p. In addition, our findings indicate a linear clonal evolution to be the predominant manner of cytogenetic evolution. Our data may provide a biological framework for the dismal outcome of progressive and relapsing Burkitt lymphoma.
- Subjects :
- Oncology
Male
Pathology
medicine.medical_specialty
Time Factors
Adolescent
Databases, Factual
Follicular lymphoma
Genes, myc
clonal evolution
CHILDHOOD
Chromosomal translocation
CHILDREN
MYC
Biology
Somatic evolution in cancer
Translocation, Genetic
CHROMOSOMAL-ABNORMALITIES
immune system diseases
Internal medicine
hemic and lymphatic diseases
ADOLESCENTS
medicine
Humans
NON-HODGKINS-LYMPHOMA
TRANSLOCATIONS
Child
In Situ Hybridization, Fluorescence
Chromosome Aberrations
relapse
Burkitt lymphoma
Karyotype
Hematology
Models, Theoretical
medicine.disease
Cytogenetic Aberrations
Lymphoma
Leukemia
GENOMIC ABERRATIONS
Child, Preschool
Karyotyping
B-CELL LYMPHOMAS
Female
progression
Neoplasm Recurrence, Local
Trisomy
Immunoglobulin Heavy Chains
FOLLICULAR LYMPHOMA
LEUKEMIA
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology, 170(6), 814-825. Wiley
- Accession number :
- edsair.doi.dedup.....ae67526b8034e5c664519cec59aeb2cc