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Active superelasticity in three-dimensional epithelia of controlled shape
- Source :
- Nature, Nature, Nature Publishing Group, 2018, 563 (7730), pp.203-208. ⟨10.1038/s41586-018-0671-4⟩, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Scipedia Open Access, Scipedia SL, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC)
- Publication Year :
- 2018
- Publisher :
- Springer Nature, 2018.
-
Abstract
- Fundamental biological processes are carried out by curved epithelial sheets that enclose a pressurized lumen. How these sheets develop and withstand three-dimensional deformations has remained unclear. Here we combine measurements of epithelial tension and shape with theoretical modelling to show that epithelial sheets are active superelastic materials. We produce arrays of epithelial domes with controlled geometry. Quantification of luminal pressure and epithelial tension reveals a tensional plateau over several-fold areal strains. These extreme strains in the tissue are accommodated by highly heterogeneous strains at a cellular level, in seeming contradiction to the measured tensional uniformity. This phenomenon is reminiscent of superelasticity, a behaviour that is generally attributed to microscopic material instabilities in metal alloys. We show that in epithelial cells this instability is triggered by a stretch-induced dilution of the actin cortex, and is rescued by the intermediate filament network. Our study reveals a type of mechanical behaviour—which we term active superelasticity—that enables epithelial sheets to sustain extreme stretching under constant tension.
- Subjects :
- 0301 basic medicine
Engineering, Civil
Materials science
Cytochalasin D
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Intermediate Filaments
Engineering, Multidisciplinary
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Epithelial cells
Cellular level
Instability
Article
Madin Darby Canine Kidney Cells
03 medical and health sciences
Dogs
Epithelium--Growth
Alloys
Pressure
Animals
Humans
Engineering, Ocean
Cytoskeleton
Intermediate filament
Engineering, Aerospace
Engineering, Biomedical
Cell Shape
ComputingMilieux_MISCELLANEOUS
Cell Size
Cèl·lules epitelials
Multidisciplinary
Elasticitat
Epithelial Cells
Computer Science, Software Engineering
Engineering, Marine
Actins
Elasticity
Biomechanical Phenomena
Engineering, Manufacturing
Engineering, Mechanical
030104 developmental biology
Engineering, Industrial
Pseudoelasticity
Biophysics
Enginyeria biomèdica::Enginyeria de teixits [Àrees temàtiques de la UPC]
Caco-2 Cells
Epiteli
Lumen (unit)
Subjects
Details
- Language :
- English
- ISSN :
- 00280836 and 14764679
- Database :
- OpenAIRE
- Journal :
- Nature, Nature, Nature Publishing Group, 2018, 563 (7730), pp.203-208. ⟨10.1038/s41586-018-0671-4⟩, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona, Scipedia Open Access, Scipedia SL, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC)
- Accession number :
- edsair.doi.dedup.....ae5fccf45dc6d19366e30e64b3e9494f