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Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders
- Source :
- Trends in Biochemical Sciences. 44:733-736
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein that regulates multiple biological processes, including paraspeckles formation and cellular signal transduction. Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). hnRNPK-lncRNAs interaction is potentially implicated in various pathogenic disorders including tumorigenesis, and Kabuki-like, Au-Kline, and Okamoto syndromes.
- Subjects :
- RNA localization
Paraneoplastic Syndromes
Cellular functions
Hydronephrosis
Biology
medicine.disease_cause
Biochemistry
Heterogeneous-Nuclear Ribonucleoprotein K
03 medical and health sciences
0302 clinical medicine
Intellectual Disability
medicine
Humans
Abnormalities, Multiple
Molecular Biology
030304 developmental biology
0303 health sciences
Facies
RNA
Hematologic Diseases
Cellular signal transduction
Paraspeckles
Cell biology
Cleft Palate
Vestibular Diseases
Face
Muscle Hypotonia
RNA, Long Noncoding
Carcinogenesis
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 09680004
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Trends in Biochemical Sciences
- Accession number :
- edsair.doi.dedup.....ae53026c87d43d268948b1fc2419e4a6