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Influence of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus on Gut Microbiota in the First Month of Life
- Source :
- Journal of pediatric gastroenterology and nutrition. 62(2)
- Publication Year :
- 2015
-
Abstract
- OBJECTIVES: The effect of intrapartum antibiotic prophylaxis (IAP) for group B Streptococcus (GBS) on bacterial colonization of the infant's gut has not been investigated extensively. We aimed to evaluate the effect of IAP on gut microbiota in healthy term infants, also exploring the influence of type of feeding. METHODS: Healthy term infants, whose mothers had been screened for GBS in late gestation, were divided into 2 groups: infants born to GBS-positive mothers who had received IAP versus controls. Neonatal fecal samples were collected at 7 and 30 days of life; DNA was extracted, and quantification of selected microbial groups (Lactobacillus spp, Bifidobacterium spp, and Bacteroides fragilis group) was performed by real-time PCR. RESULTS: A total of 84 infant-mother pairs were recruited. Bifidobacteria count was significantly lower in the IAP group at 7 days of life (median [interquartile range] 6.01 Log colony-forming unit per gram [5.51-6.98] vs 7.80 [6.61-8.26], P = 0.000). No differences in Bifidobacteria count at 30 days or in Lactobacilli and B fragilis counts at any time point were documented. Furthermore, at 7 days of life, infants who had not received IAP and were exclusively human milk-fed had higher counts of Bifidobacteria. Regardless of IAP treatment, infants fed exclusively human milk had higher Lactobacillus spp counts both at 7 and 30 days of life. CONCLUSIONS: IAP alters gut microflora by reducing the count of Bifidobacteria, which is further affected in infants receiving formula feeding. Whether these alterations could have long-term consequences on health and disease requires further investigation.
- Subjects :
- Male
Gut flora
medicine.disease_cause
Group B
Feces
0302 clinical medicine
Pregnancy
Bacteroides
030212 general & internal medicine
Antibiotic prophylaxis
Pregnancy Complications, Infectious
reproductive and urinary physiology
biology
Streptococcus
Gastroenterology
food and beverages
Infant Formula
Anti-Bacterial Agents
Female
Adult
DNA, Bacterial
Real-Time Polymerase Chain Reaction
digestive system
Streptococcus agalactiae
03 medical and health sciences
Bacterial colonization
030225 pediatrics
Streptococcal Infections
medicine
Humans
Retrospective Studies
Milk, Human
business.industry
Infant
Intrapartum Antibiotic Prophylaxis , Group B Streptococcus, Gut Microbiota, newborn
Retrospective cohort study
Feeding Behavior
Antibiotic Prophylaxis
biology.organism_classification
medicine.disease
Infectious Disease Transmission, Vertical
Gastrointestinal Microbiome
body regions
Gastrointestinal Tract
Lactobacillus
Infant formula
Pediatrics, Perinatology and Child Health
Immunology
Bifidobacterium
business
Subjects
Details
- ISSN :
- 15364801
- Volume :
- 62
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of pediatric gastroenterology and nutrition
- Accession number :
- edsair.doi.dedup.....ae514ba8d01c004abf9f1b3aa4cba5cb