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Alcohol and oestrogen metabolites in postmenopausal women in the Women’s Health Initiative Observational Study
- Source :
- British Journal of Cancer
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Background: Alcohol consumption is associated with an increased risk of several cancers. Potential mechanisms include altered oestrogen metabolism. Parent oestrogens metabolise into alternate pathways of oestrogen metabolites that may have variable effects on cancer pathogenesis. We examined associations of alcohol consumption with circulating oestrogen/oestrogen metabolites in postmenopausal women in the Women’s Health Initiative (WHI)-Observational Study (OS). Methods: We conducted a cross-sectional analysis of prediagnosis ovarian/endometrial cancer case-control data within WHI-OS (N=1864). Alcohol consumption was measured by validated food frequency questionnaire. Fasting serum parent oestrogens/oestrogen metabolites were assayed using liquid chromatography tandem mass-spectrometry. Geometric mean analyte concentrations (GM, pmol l−1) were calculated by alcohol category using inverse-probability weighted linear regression, adjusting for venepuncture age/year, race, smoking, body mass index, years since menopause, oral contraceptive duration, caffeine intake, and physical activity. Results: There was evidence for a positive association between alcohol consumption and oestrone, oestradiol and 2-hydroxylation oestrogen metabolite concentrations among menopausal hormone therapy (MHT) users. We observed an association between liquor consumption and parent oestrogens among non-MHT users, who consumed larger doses of liquor than MHT users. Conclusions: Among postmenopausal women, the association between alcohol intake and parent oestrogen, but not oestrogen metabolite concentrations, may be influenced by MHT and type of alcohol.
- Subjects :
- 0301 basic medicine
Cancer Research
Alcohol Drinking
Cross-sectional study
Epidemiology
Estrone
Metabolite
Physiology
Alcohol
sex hormones
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Surveys and Questionnaires
medicine
Humans
skin and connective tissue diseases
metabolites
Aged
Ovarian Neoplasms
postmenopausal
Estradiol
business.industry
alcohol
Endometrial cancer
Women's Health Initiative
Estrogen Replacement Therapy
Case-control study
Estrogens
Middle Aged
medicine.disease
metabolomics
Endometrial Neoplasms
Menopause
Postmenopause
030104 developmental biology
Cross-Sectional Studies
Oncology
chemistry
030220 oncology & carcinogenesis
Case-Control Studies
Female
business
oestrogen
Body mass index
metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 118
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....ae460ae74aa0200f3b32c5acee0bd52b