Therapeutic effects of silodosin and urapidil on underactive bladder associated with diabetic cystopathy

Pharmacological treatment options for underactive bladder (UAB) syndrome are limited. Urapidil is the only alphaChanges in intraurethral pressure (IUP) induced by midodrine (alphaBoth silodosin and urapidil inhibited the midodrine-induced increase in IUP and decreased MBP in a dose-dependent manner. Silodosin had a more substantial effect on the lower urinary tract than on MBP. Twelve weeks after STZ administration, DM rats exhibited UAB-like dysfunction (increased bladder capacity/bladder weight and residual volume and decreased bladder voided efficiency) and decreased BBF. Both drug treatments controlled this dysfunction.Alpha