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Neuromuscular block by circulating D-tubocurarine residue following uptake and distribution
- Source :
- Canadian Anaesthetists' Society journal. 24(4)
- Publication Year :
- 1977
-
Abstract
- Serum concentration of d-tubocurarine decreases rapidly after intravenous injection because of uptake and distribution. The circulating residue of an ED 50 dose of d-tubocurarine five minutes after injection will produce no block in a previously unexposed neuromuscular junction. To produce a 50 per cent block with the circulating d-tubocurarine residue in a previously unexposed neuromuscular junction requires an initial injection of 2.5 x ED 50 dose. Five minutes after a dose 5 to 6 times the ED 50, the plasma d-tubocurarine residue is sufficient to produce a total block.
- Subjects :
- Male
Residue (complex analysis)
medicine.medical_specialty
Time Factors
business.industry
Neuromuscular Junction
Tubocurarine
General Medicine
Serum concentration
Synaptic Transmission
D-Tubocurarine
Anesthesiology and Pain Medicine
Endocrinology
Anesthesia
Internal medicine
medicine
Cats
Distribution (pharmacology)
Animals
Female
business
Muscle Contraction
Subjects
Details
- ISSN :
- 00082856
- Volume :
- 24
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Canadian Anaesthetists' Society journal
- Accession number :
- edsair.doi.dedup.....ae42458dd7b4e0367849d1bea6f29a9e