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Dysregulation of TMPRSS3 and TNFRSF11B correlates with tumorigenesis and poor prognosis in patients with breast cancer
- Source :
- Oncology reports. 37(4)
- Publication Year :
- 2016
-
Abstract
- The present study was carried out to investigate the clinical significance of TMPRSS3 and TNFRSF11B in breast cancer. Thus, the expression levels of TMPRSS3 and TNFRSF11B and the correlation with prognosis in patients with breast cancer were analyzed in silico using gene microarray and hierarchical clustering analysis. Then, the differential expression in breast cancer vs. normal breast tissue was explored in the Oncomine platform and verified in our independent samples using IHC technique. Our results indicated that TMPRSS3 was upregulated and TNFRSF11B was downregulated in breast cancer tissues compared with the levels in the human normal breast tissues. TMPRSS3 and TNFRSF11B were confirmed to be correlated with distant organ metastasis of breast cancer. Moreover, upregulation of TMPRSS3 accompanied by downregulation of TNFRSF11B was found to be associated with a shorter median overall survival and indicated a poor prognosis. In conclusion, TMPRSS3 and TNFRSF11B may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Carcinogenesis
Breast Neoplasms
Biology
medicine.disease_cause
Disease-Free Survival
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Biomarkers, Tumor
Humans
Clinical significance
Neoplasm Metastasis
skin and connective tissue diseases
Oncogene
Serine Endopeptidases
Osteoprotegerin
Cancer
Membrane Proteins
General Medicine
medicine.disease
Prognosis
Molecular medicine
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Immunohistochemistry
Female
Subjects
Details
- ISSN :
- 17912431
- Volume :
- 37
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....ae3dac92bdb957376ca6978f559b5378