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Biomarker signatures of aging
- Source :
- Aging Cell
- Publication Year :
- 2017
- Publisher :
- John Wiley and Sons Inc., 2017.
-
Abstract
- Summary Because people age differently, age is not a sufficient marker of susceptibility to disabilities, morbidities, and mortality. We measured nineteen blood biomarkers that include constituents of standard hematological measures, lipid biomarkers, and markers of inflammation and frailty in 4704 participants of the Long Life Family Study (LLFS), age range 30–110 years, and used an agglomerative algorithm to group LLFS participants into clusters thus yielding 26 different biomarker signatures. To test whether these signatures were associated with differences in biological aging, we correlated them with longitudinal changes in physiological functions and incident risk of cancer, cardiovascular disease, type 2 diabetes, and mortality using longitudinal data collected in the LLFS. Signature 2 was associated with significantly lower mortality, morbidity, and better physical function relative to the most common biomarker signature in LLFS, while nine other signatures were associated with less successful aging, characterized by higher risks for frailty, morbidity, and mortality. The predictive values of seven signatures were replicated in an independent data set from the Framingham Heart Study with comparable significant effects, and an additional three signatures showed consistent effects. This analysis shows that various biomarker signatures exist, and their significant associations with physical function, morbidity, and mortality suggest that these patterns represent differences in biological aging. The signatures show that dysregulation of a single biomarker can change with patterns of other biomarkers, and age-related changes of individual biomarkers alone do not necessarily indicate disease or functional decline.
- Subjects :
- 0301 basic medicine
Adult
Male
Aging
Longevity
Type 2 diabetes
Disease
Physical function
Bioinformatics
03 medical and health sciences
Framingham Heart Study
Age Distribution
medicine
Humans
Family
Mortality
Aged
Aged, 80 and over
Successful aging
business.industry
morbidity and mortality
Cancer
biomarkers
Reproducibility of Results
Cell Biology
Original Articles
Middle Aged
medicine.disease
3. Good health
030104 developmental biology
healthy aging
Blood biomarkers
biological aging
Calibration
Biomarker (medicine)
Original Article
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 14749726 and 14749718
- Volume :
- 16
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Aging Cell
- Accession number :
- edsair.doi.dedup.....ae391e1756a68e7007fc991715badb58