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SOAT1 methylation is associated with coronary heart disease
- Source :
- Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-6 (2019), Lipids in Health and Disease
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate genes FLOT1, FLOT2 and SOAT1 were measured in peripheral blood leukocytes (PBLs) from 99 patients diagnosed with CHD and 89 control subjects without CHD. A total of 110 CPG sites around promoter regions of them were examined. Results Compared with groups without CHD, patients with CHD had lower methylation levels of SOAT1 (PP = 0.005). After adjustment of other confounders, methylation levels of SOAT1 were still associated with CHD (P = 0.001, OR = 0.290, 95% CI: 0.150–0.561). Conclusions SOAT1 methylation may be associated with development of CHD. Patients with lower methylation levels in SOAT1 may have increased risks for CHD. Further studies on the specific mechanisms of this relationship are necessary.
- Subjects :
- Male
0301 basic medicine
Oncology
Candidate gene
medicine.medical_specialty
Genotype
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Coronary Disease
Clinical nutrition
03 medical and health sciences
0302 clinical medicine
Endocrinology
Risk Factors
Internal medicine
Leukocytes
Humans
Medicine
Cholesterol absorption
cardiovascular diseases
Promoter Regions, Genetic
lcsh:RC620-627
Aged
DNA methylation
business.industry
Research
Biochemistry (medical)
Confounding
Methylation
Middle Aged
Coronary heart disease
lcsh:Nutritional diseases. Deficiency diseases
030104 developmental biology
CpG site
030220 oncology & carcinogenesis
Biomarker (medicine)
CpG Islands
Female
business
SOAT1
Sterol O-Acyltransferase
Lipidology
Subjects
Details
- Language :
- English
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....ae3125691d05f66aa57732a6479c5c17