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Impact of resection margins on long-term survival after pancreaticoduodenectomy for pancreatic head carcinoma
- Source :
- World Journal of Clinical Cases
- Publication Year :
- 2019
- Publisher :
- Baishideng Publishing Group Inc., 2019.
-
Abstract
- BACKGROUND The impact of resection margin status on long-term survival after pancreaticoduodenectomy (PD) for patients with pancreatic head carcinoma remains controversial and depends on the method used in the histopathological study of the resected specimens. This study aimed to examine the impact of resection margin status on the long-term overall survival of patients with pancreatic head carcinoma after PD using the tumor node metastasis standard. METHODS Consecutive patients with pancreatic head carcinoma who underwent PD at the Chinese People's Liberation Army General Hospital between May 2010 and May 2016 were included. The impact of resection margin status on long-term survival was retrospectively analyzed. RESULTS Among the 124 patients, R0 resection was achieved in 85 patients (68.5%), R1 resection in 38 patients (30.7%) and R2 resection in 1 patient (0.8%). The 1- and 3-year overall survival (OS) rates were significantly higher for the patients who underwent R0 resection than the rates for those who underwent R1 resection (1-year OS rates: 69.4% vs 53.0%; 3-year OS rates: 26.9% vs 11.7%). Multivariate analysis showed that resection margin status and venous invasion were significant risk factors for OS. CONCLUSION Resection margin was an independent risk factor for OS for patients with pancreatic head carcinoma after PD. R0 resection was associated with significantly better OS after surgery.
- Subjects :
- medicine.medical_specialty
R0 resection margin
Disease-free survival
R1 resection
medicine.medical_treatment
Pancreatic head
Pancreaticoduodenectomy
Resection
03 medical and health sciences
0302 clinical medicine
Retrospective Study
Long term survival
Carcinoma
Overall survival
Medicine
Pancreatic head cancer
business.industry
General Medicine
medicine.disease
Surgery
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 23078960
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- World Journal of Clinical Cases
- Accession number :
- edsair.doi.dedup.....ae2f5caf1bcbd14d563c2b24b1529e25