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Clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay in the management of women referred to colposcopy with minor cytological abnormalities
- Source :
- Diagnostic Cytopathology. 46:987-992
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background The aim of this study was to evaluate the clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay for the detection of CIN2+ disease in women referred to colposcopy with minor cytological abnormalities. Methods ThinPrep liquid-based cytology samples were collected from 562 women referred to colposcopy with minor cytological abnormalities. HPV testing by both assays was performed on these samples. Clinical performances for detection of histologically diagnosed CIN2+ and CIN3+ were calculated. Results HPV prevalence by the Cobas 4800 HPV test was 58.2% and 53.0% women tested positive with the Aptima HPV assay in the entire study population. The Aptima HPV assay and the Cobas 4800 HPV test displayed equivalent sensitivity of 90.2% (95%CI, 83.4-94.9) for the detection of CIN2+ disease. However, the Aptima HPV assay displayed greater specificity of 61.0% (95% CI, 54.0-68.0) when compared to the Cobas 4800 HPV test 53.0% (95% CI, 46.0-60.0), and this was significantly higher (P = .0004). The Aptima HPV assay also displayed higher specificity 76.5% (95% CI, 66.0-85.0) in the ASCUS category in comparison to the Cobas 4800 HPV test 65.0% (95% 54.0-75.0) which was statistically significant (P = .004). Conclusions Both the tests displayed similar sensitivity. However, the Aptima HPV assay was significantly more specific in the identification of women with CIN2+ disease in a colposcopy referral population.
- Subjects :
- Adult
0301 basic medicine
medicine.medical_specialty
Histology
030106 microbiology
Population
Cervical intraepithelial neoplasia
Sensitivity and Specificity
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Cytology
medicine
Humans
education
Papillomaviridae
Cervix
Early Detection of Cancer
Vaginal Smears
Gynecology
Colposcopy
Cervical cancer
education.field_of_study
medicine.diagnostic_test
business.industry
Papillomavirus Infections
virus diseases
General Medicine
medicine.disease
female genital diseases and pregnancy complications
medicine.anatomical_structure
030220 oncology & carcinogenesis
Population study
Biological Assay
Female
business
Ascus
Subjects
Details
- ISSN :
- 87551039
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Diagnostic Cytopathology
- Accession number :
- edsair.doi.dedup.....ae2f151690fe3fb2b3344c78a642f577