Back to Search
Start Over
Nephroprotective effects of chlorogenic acid against sodium arsenite-induced oxidative stress, inflammation, and apoptosis
- Source :
- Journal of the science of food and agricultureREFERENCES. 100(14)
- Publication Year :
- 2020
-
Abstract
- Background Chronic exposure to arsenic (As) leads to serious renal disorders. Chlorogenic acid (CGA), a phenolic compound, has several well known physiological benefits, including antioxidant and anti-inflammatory activities. The present study investigated the potential renoprotective effects of CGA on sodium arsenite (NaAsO2 )-induced kidney damage in mice. The mice were randomly allocated into five groups to receive daily treatment with CGA (200 mg kg-1 ), NaAsO2 (5 mg kg-1 ), NaAsO2 + CGA (100 mg kg-1 ), NaAsO2 + CGA (200 mg kg-1 ), or a control for 28 days. Results In the NaAsO2 -treated group, NaAsO2 induced significant renal dysfunction, oxidative damage, inflammation, and apoptosis, as demonstrated by marked increases in urea and creatinine levels accompanied by a decrease in the kidney index. Considerable increases in malondialdehyde and nitric oxide levels and parallel decreases in various antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione) levels were also detected in the renal tissues of NaAsO2 -treated mice. NaAsO2 exposure was associated with marked increases in renal inflammatory markers (interleukin-1β and tumor necrosis factor-α) and apoptosis indicators including Bax and caspase-3 levels contaminant, with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2 -treated group compared with the control group. However, pretreatment with CGA substantially mitigated the renal injury and dysfunction associated with NaAsO2 exposure by reducing tissue inflammation and apoptosis and improving the antioxidant status. The CGA pretreatment also alleviated the NaAsO2 -induced histological alterations in renal tissues. Conclusion Taken together, our results suggest the efficacy of CGA in alleviating As-mediated renal tissue damage. © 2020 Society of Chemical Industry.
- Subjects :
- Male
endocrine system
Sodium arsenite
Antioxidant
030309 nutrition & dietetics
Arsenites
medicine.medical_treatment
Glutathione reductase
Anti-Inflammatory Agents
Apoptosis
Pharmacology
medicine.disease_cause
Kidney
Protective Agents
Nephrotoxicity
03 medical and health sciences
chemistry.chemical_compound
Mice
0404 agricultural biotechnology
medicine
Animals
Humans
chemistry.chemical_classification
0303 health sciences
Nutrition and Dietetics
Glutathione peroxidase
04 agricultural and veterinary sciences
Glutathione
040401 food science
Sodium Compounds
Oxidative Stress
medicine.anatomical_structure
chemistry
Kidney Diseases
Chlorogenic Acid
Agronomy and Crop Science
Oxidative stress
Food Science
Biotechnology
Subjects
Details
- ISSN :
- 10970010
- Volume :
- 100
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of the science of food and agricultureREFERENCES
- Accession number :
- edsair.doi.dedup.....ae1a37e8fbd75327687c234b34b5cfc6