Back to Search
Start Over
Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome
- Source :
- European Journal of Endocrinology. 159:381-388
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- ObjectiveGhrelin is secreted primarily by the stomach and circulates as both acylated and desacyl ghrelin. Acylated (but not desacyl) ghrelin stimulates appetite. Both concentrations are elevated in Prader–Willi syndrome (PWS), suggesting that ghrelin may contribute to hyperphagia and overweight in these subjects. We evaluated whether long-acting octreotide (Oct) decreases acylated and desacyl ghrelin concentrations, body mass, appetite and compulsive behaviour towards food in adolescents with PWS.DesignA 56-week prospective, randomized, cross-over trial.MethodsNine subjects with PWS (age 14.6 (10.8–18.9) years, body mass index (BMI) Z-score +1.9 (0.6–3.0)) received either Oct (30 mg) or saline i.m. every 4 weeks for 16 weeks and were switched over to the other treatment after a 24-week washout period.ResultsEight subjects completed the study. Oct caused a decrease in both acylated (−53%) and desacyl (−54%) fasting ghrelin concentrations (PConclusionsOct treatment caused a prolonged decrease in ghrelin concentrations in adolescents with PWS but did not improve body mass or appetite. Future intervention studies aiming at clarifying the role of ghrelin in PWS should focus on the administration of specific inhibitors of ghrelin secretion or ghrelin receptor activity that do not interfere with other appetite-regulating peptides.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Appetite
Octreotide
Gallbladder Diseases
Peptide hormone
Body Mass Index
Endocrinology
Gastrointestinal Agents
Internal medicine
medicine
Homeostasis
Humans
Peptide YY
Insulin-Like Growth Factor I
Child
Ultrasonography
media_common
Cross-Over Studies
business.industry
Body Weight
digestive, oral, and skin physiology
Feeding Behavior
General Medicine
Crossover study
Body Height
Ghrelin
Body Composition
Female
business
Prader-Willi Syndrome
Body mass index
Ghrelin secretion
medicine.drug
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 159
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....ae1587107dc67051ba6dd9e5ba2b7afd