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Functional Connectivity and Structural Disruption in the Default‐Mode Network Predicts Cognitive Rehabilitation Outcomes in Multiple Sclerosis
- Source :
- Journal of Neuroimaging. 30:523-530
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background and purpose Efficacy of restorative cognitive rehabilitation can be predicted from baseline patient factors. In addition, patient profiles of functional connectivity are associated with cognitive reserve and moderate the structure-cognition relationship in people with multiple sclerosis (PwMS). Such interactions may help predict which PwMS will benefit most from cognitive rehabilitation. Our objective was to determine whether patient response to restorative cognitive rehabilitation is predictable from baseline structural network disruption and whether this relationship is moderated by functional connectivity. Methods For this single-arm repeated measures study, we recruited 25 PwMS for a 12-week program. Following magnetic resonance imaging, participants were tested using the Symbol Digit Modalities Test (SDMT) pre- and postrehabilitation. Baseline patterns of structural and functional connectivity were characterized relative to healthy controls. Results Lower white matter tract disruption in a network of region-pairs centered on the precuneus and posterior cingulate (default-mode network regions) predicted greater postrehabilitation SDMT improvement (P = .048). This relationship was moderated by profiles of functional connectivity within the network (R2 = .385, P = .017, Interaction β = -.415). Conclusion Patient response to restorative cognitive rehabilitation is predictable from the interaction between structural network disruption and functional connectivity in the default-mode network. This effect may be related to cognitive reserve.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Precuneus
Neuropsychological Tests
030218 nuclear medicine & medical imaging
03 medical and health sciences
Cognition
0302 clinical medicine
Physical medicine and rehabilitation
cognitive rehabilitation
functional MRI
multiple sclerosis
network
prediction
medicine
Humans
Radiology, Nuclear Medicine and imaging
Cognitive rehabilitation therapy
Default mode network
Aged
Cognitive reserve
medicine.diagnostic_test
business.industry
Multiple sclerosis
Brain
Default Mode Network
Repeated measures design
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
White Matter
Treatment Outcome
medicine.anatomical_structure
Posterior cingulate
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15526569 and 10512284
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimaging
- Accession number :
- edsair.doi.dedup.....ae0ee3a8c3a973f7fb829dad380c0dce