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Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview
- Source :
- Frontiers in Bioengineering and Biotechnology, Vol 8 (2020), Frontiers in Bioengineering and Biotechnology
- Publication Year :
- 2020
- Publisher :
- Frontiers Media S.A., 2020.
-
Abstract
- Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells. For decades, one of the most important applications of riboflavin has been its global use as an animal and human nutritional supplement. Being well-informed of the latest research on riboflavin production via the fermentation process is necessary for the development of new and improved microbial strains using biotechnology and metabolic engineering techniques to increase vitamin B2 yield. In this review, we describe well-known industrial microbial producers, namely, Ashbya gossypii, Bacillus subtilis, and Candida spp. and summarize their biosynthetic pathway optimizations through genetic and metabolic engineering, combined with random chemical mutagenesis and rational medium components to increase riboflavin production.
- Subjects :
- 0301 basic medicine
vitamin B2
Histology
lcsh:Biotechnology
Biomedical Engineering
Flavin mononucleotide
Riboflavin
Bioengineering
Review
02 engineering and technology
Bacillus subtilis
Cofactor
Metabolic engineering
03 medical and health sciences
chemistry.chemical_compound
genetically modified microorganisms
lcsh:TP248.13-248.65
heterocyclic compounds
riboflavin
Flavin adenine dinucleotide
biology
Bioengineering and Biotechnology
food and beverages
021001 nanoscience & nanotechnology
Micronutrient
biology.organism_classification
food/feed additive
030104 developmental biology
chemistry
Biochemistry
biology.protein
Fermentation
0210 nano-technology
metabolic engineering
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 22964185
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Bioengineering and Biotechnology
- Accession number :
- edsair.doi.dedup.....ae0eadd09f2094e095820102169a5710