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Prolactin receptor does not correlate with oestrogen and progesterone receptors in primary breast cancer and lacks prognostic significance. Ten year results of the Naples adjuvant (GUN) study
- Source :
- British Journal of Cancer
- Publication Year :
- 1990
-
Abstract
- The correlation between prolactin (PRLR) and oestrogen (ER) or progesterone receptors (PgR) in breast cancer and a possible prognostic significance of PRLR at 10 year follow-up have been investigated in the Naples (GUN) adjuvant trial. A total of 308 pre- and post-menopausal patients with early breast cancer, who entered the trial from 1 February 1978 to 31 December 1983, received randomly Tamoxifen (TM), 30 mg per die for 2 years, or no therapy. PRLR status was known in 229 (74.3\%) patients. Values of specific binding less than 1\% were considered negative. PRLR was positive in 75/229 (32.8\%). ER was assayed in 210/229 (91.7\%) patients and PgR in 188/229 (82.1\%). No significant correlation, by the Spearman test, was found between PRLR and ER or PgR, while ER status was highly interrelated with PgR status. By the Cox model no evidence of an independent prognostic role of PRLR on disease-free survival (DFS) was observed, nor an interaction between PRLR and adjuvant treatment with TM was found.
- Subjects :
- Oncology
Adult
Cancer Research
medicine.medical_specialty
Receptors, Prolactin
Mammary gland
Breast Neoplasms
predictive factor
Breast cancer
breast cancer
Internal medicine
medicine
Humans
prolactin receptors
Receptor
skin and connective tissue diseases
Survival rate
business.industry
Proportional hazards model
Prolactin receptor
Middle Aged
medicine.disease
Prognosis
Prolactin
Survival Rate
medicine.anatomical_structure
Endocrinology
Receptors, Estrogen
Female
business
Receptors, Progesterone
Tamoxifen
medicine.drug
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 62
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....ae0b5a975402de3a9cf3ce006c646c16