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Thyroperoxidase and Thyroglobulin Antibodies in Early Pregnancy and Placental Abruption
- Source :
- Obstetrics & Gynecology. 117:287-292
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- Objective To estimate the relationship between thyroid antibodies and placental abruption. Methods This cohort study assesses thyroperoxidase and thyroglobulin antibodies in relation to placental abruption among 10,062 women with singleton viable pregnancies (from the First and Second Trimester Risk of Aneuploidy [FaSTER] trial). A thyroperoxidase antibody cutoff of 50 international units/mL is used for comparison with published data from another cohort. Results Women with elevated thyroperoxidase antibody levels in the first and second trimesters have a higher rate of placental abruption than antibody-negative women. This relationship is less strong in the first trimester (1.51% compared with 0.83%; odds ratio [OR], 1.83; 95% confidence interval [CI], 0.99-3.37) than in the second trimester (1.78% compared with 0.82%; OR, 2.20; 95% CI, 1.21-3.99). A similar, but weaker, relationship is present for thyroglobulin antibodies. Sixty-four of 782 thyroperoxidase antibody-positive pregnancies without abruption become negative by the second trimester; one pregnancy with abruption becomes antibody-positive. Odds ratios for pregnancies with both thyroperoxidase and thyroglobulin antibody elevations are also higher (first trimester: OR, 2.10; 95% CI, 0.91-4.86; second trimester: OR, 2.73; 95% CI, 1.17-6.33). Conclusion The present data confirm an association between thyroid antibody elevations and placental abruption described in a recent report. These findings, however, do not provide support for recommending routine testing for thyroid antibodies during pregnancy. Level of evidence II.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Iodide Peroxidase
Thyroglobulin
Cohort Studies
Young Adult
Pregnancy
Thyroid peroxidase
medicine
Humans
Abruptio Placentae
Gynecology
Placental abruption
biology
business.industry
Obstetrics
Obstetrics and Gynecology
Odds ratio
medicine.disease
Anti-thyroid autoantibodies
Pregnancy Trimester, Second
Cohort
biology.protein
Female
business
Cohort study
Subjects
Details
- ISSN :
- 00297844
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Obstetrics & Gynecology
- Accession number :
- edsair.doi.dedup.....ae0943c9410087555c7589601868f308