Back to Search
Start Over
Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations
- Source :
- npj Breast Cancer, Vol 4, Iss 1, Pp 1-7 (2018), NPJ breast cancer, 4 (1, NPJ Breast Cancer
- Publication Year :
- 2018
- Publisher :
- NATURE PUBLISHING GROUP, 2018.
-
Abstract
- Breast cancer diagnosed during pregnancy (BCP) is a rare and highly challenging disease. To investigate the impact of pregnancy on the biology of breast cancer, we conducted a comparative analysis of a cohort of BCP patients and non-pregnant control patients by integrating gene expression, copy number alterations and whole genome sequencing data. We showed that BCP exhibit unique molecular characteristics including an enrichment of non-silent mutations, a higher frequency of mutations in mucin gene family and an enrichment of mismatch repair deficiency mutational signature. This provides important insights into the biology of BCP and suggests that these features may be implicated in promoting tumor progression during pregnancy. In addition, it provides an unprecedented resource for further understanding the biology of breast cancer in young women and how pregnancy could modulate tumor biology.<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Silent mutation
Disease
medicine.disease_cause
lcsh:RC254-282
Article
03 medical and health sciences
0302 clinical medicine
Breast cancer
Nuclear Medicine and Imaging
Medicine
Gene family
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
HETEROGENEITY
Whole genome sequencing
Pregnancy
Science & Technology
LANDSCAPE
business.industry
Oncology
Radiology, Nuclear Medicine and Imaging
Généralités
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
PD-1 BLOCKADE
TUMORS
3. Good health
030104 developmental biology
Tumor progression
030220 oncology & carcinogenesis
Cancer research
Radiology
business
Carcinogenesis
Life Sciences & Biomedicine
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- npj Breast Cancer, Vol 4, Iss 1, Pp 1-7 (2018), NPJ breast cancer, 4 (1, NPJ Breast Cancer
- Accession number :
- edsair.doi.dedup.....ae07bf758f3543664782182e8b713e04