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Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds
- Source :
- Applied Surface Science, Applied Surface Science, 2015, 353, pp.200-208. ⟨10.1016/j.apsusc.2015.06.146⟩, Applied Surface Science, Elsevier, 2015, 353, pp.200-208. ⟨10.1016/j.apsusc.2015.06.146⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Chitosan scaffolds, combined with bioactive glass 46S6, were prepared to serve as gentamicin sulfate delivery in situ systems for bone biomaterials. This work presents a study about the effect of the ratio chitosan/bioactive glass (CH/BG) on the release of gentamicin sulfate and on the bioactivity during in vitro experiments. SEM observations allowed understanding the bond between the glass grains and the chitosan matrix. In vitro results showed that scaffolds form a hydroxyapatite (HA) Ca10(PO4)6(OH)2 after 15 days of immersion in a simulated body fluid (SBF).The interest of this study is to see that the increase of the content of bioactive glass in the chitosan matrix slows the release of gentamicin sulfate in the liquid medium. Starting concentration of gentamicin sulfate has an influence on the relaxation time of the scaffolds. Indeed, an increasing concentration delays the return to a new equilibrium. Contents of chitosan and bioactive glass do not affect the relaxation time. Synthesized scaffolds could be adapted to a clinical situation: severity and type of infection, weight and age of the patient.
- Subjects :
- Scaffolds
Chitosan
Materials science
Simulated body fluid
Drug delivery system
General Physics and Astronomy
Biomaterial
Relaxation time
Surfaces and Interfaces
General Chemistry
Liquid medium
Matrix (biology)
Condensed Matter Physics
Surfaces, Coatings and Films
law.invention
chemistry.chemical_compound
Gentamicin Sulfate
chemistry
law
Bioactive glass
[CHIM]Chemical Sciences
Composite material
Nuclear chemistry
Gentamicin sulfate
Subjects
Details
- Language :
- English
- ISSN :
- 01694332
- Database :
- OpenAIRE
- Journal :
- Applied Surface Science, Applied Surface Science, 2015, 353, pp.200-208. ⟨10.1016/j.apsusc.2015.06.146⟩, Applied Surface Science, Elsevier, 2015, 353, pp.200-208. ⟨10.1016/j.apsusc.2015.06.146⟩
- Accession number :
- edsair.doi.dedup.....ae008419689c5fffb5c2cb0f3da7dc46