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The role of transforming growth factor-β signalling in the patterning of the proximal processes of the murine dentary
- Source :
- Anthwal, N, Chai, Y & Tucker, A S 2008, ' The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary ', Developmental Dynamics, vol. 237, no. 6, pp. 1604-1613 . https://doi.org/10.1002/dvdy.21567
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- The evolution of the novel mammalian jaw articulation has resulted in an increased complexity of the dentary bone, reflecting the multiple roles it now fulfils as the primary bone of the mandible. Signalling through the Tgf-β type II receptor is important in the development and patterning of the proximal dentary processes, especially the angular process, and secondary cartilages. We show that expression of Tgf-β2 is associated with the developing angular process, and that the connective tissue marker Scleraxis is co-expressed with Tgf-β2. Scleraxis expression is lost around the angular process of Tgfbr2 conditional knockouts and Tgf-β signalling can induce Scleraxis expression in explant culture. Induction of secondary cartilages in explant culture can be prevented by inhibition of Tgf-β signalling. This study suggests that the proper development of the processes and their secondary cartilages relies on both Tgf-β signalling and mechanical forces working in concert. Developmental Dynamics 237:1604–1613, 2008. © 2008 Wiley-Liss, Inc.
- Subjects :
- Time Factors
Connective tissue
Mandible
Protein Serine-Threonine Kinases
Biology
Mice
Organ Culture Techniques
Transforming Growth Factor beta
Basic Helix-Loop-Helix Transcription Factors
medicine
Animals
Process (anatomy)
In Situ Hybridization
Gene knockout
Body Patterning
Gene Expression Profiling
Scleraxis
Receptor, Transforming Growth Factor-beta Type II
Gene Expression Regulation, Developmental
Anatomy
Cell biology
Cartilage
Phenotype
medicine.anatomical_structure
Primary bone
Receptors, Transforming Growth Factor beta
Signal Transduction
Developmental Biology
Transforming growth factor
Explant culture
Subjects
Details
- ISSN :
- 10970177 and 10588388
- Volume :
- 237
- Database :
- OpenAIRE
- Journal :
- Developmental Dynamics
- Accession number :
- edsair.doi.dedup.....adff47c455351f1e485761bcbb939c55