The Genetic Complexity of Prostate Cancer

Authors :: Gabriel Wasinger
Renate Kain
Eva Compérat
Geraldine Cancel-Tassin
Olivier Cussenot
André Oszwald
Centre de Recherche pour les Pathologies Prostatiques [Paris] (CeRePP)
Sorbonne Université (SU)
Service de Pathologie [CHU Tenon]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP]
Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Medizinische Universität Wien = Medical University of Vienna
Sorbonne Université - Faculté de Médecine (SU FM)
Service d'urologie [CHU Tenon]
Source :: Genes, Genes, MDPI, 2020, 11 (12), pp.1396. ⟨10.3390/genes11121396⟩, Genes, Vol 11, Iss 1396, p 1396 (2020)
Publication Year :: 2020
Publisher :: HAL CCSD, 2020.
Abstract: International audience; Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge.

Language :: English
ISSN :: 20734425
Database :: OpenAIRE
Journal :: Genes, Genes, MDPI, 2020, 11 (12), pp.1396. ⟨10.3390/genes11121396⟩, Genes, Vol 11, Iss 1396, p 1396 (2020)
Accession number :: edsair.doi.dedup.....adfec4c363df57eda66590dc58ac7260
Full Text :: https://doi.org/10.3390/genes11121396⟩