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Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Volume 23, Issue 6, Molecules, Vol 23, Iss 6, p 1312 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Growing evidence shows that the neuroendocrine immunomodulation (NIM) network plays an important role in maintaining and modulating body function and the homeostasis of the internal environment. The disequilibrium of NIM in the body is closely associated with many diseases. In the present study, we first collected a core dataset of NIM signaling molecules based on our knowledge and obtained 611 NIM signaling molecules. Then, we built a NIM molecular network based on the MetaCore database and analyzed the signaling transduction characteristics of the core network. We found that the endocrine system played a pivotal role in the bridge between the nervous and immune systems and the signaling transduction between the three systems was not homogeneous. Finally, employing the forest algorithm, we identified the molecular hub playing an important role in the pathogenesis of rheumatoid arthritis (RA) and Alzheimer&rsquo<br />s disease (AD), based on the NIM molecular network constructed by us. The results showed that GSK3B, SMARCA4, PSMD7, HNF4A, PGR, RXRA, and ESRRA might be the key molecules for RA, while RARA, STAT3, STAT1, and PSMD14 might be the key molecules for AD. The molecular hub may be a potentially druggable target for these two complex diseases based on the literature. This study suggests that the NIM molecular network in this paper combined with the forest algorithm might provide a useful tool for predicting drug targets and understanding the pathogenesis of diseases. Therefore, the NIM molecular network and the corresponding online tool will not only enhance research on complex diseases and system biology, but also promote the communication of valuable clinical experience between modern medicine and Traditional Chinese Medicine (TCM).
- Subjects :
- rheumatoid arthritis
0301 basic medicine
Cell signaling
Modern medicine
Systems biology
Druggability
Pharmaceutical Science
Core network
Disease
Computational biology
Biology
Article
drug target
Analytical Chemistry
lcsh:QD241-441
Arthritis, Rheumatoid
Immunomodulation
03 medical and health sciences
0302 clinical medicine
lcsh:Organic chemistry
Neuroendocrine Cells
Alzheimer Disease
Drug Discovery
Humans
Gene Regulatory Networks
disease network
neuroendocrine immunomodulation network
Physical and Theoretical Chemistry
Gene Expression Profiling
pathogenesis
PSMD14
Organic Chemistry
Molecular network
030104 developmental biology
Chemistry (miscellaneous)
Molecular Medicine
Transcriptome
Alzheimer’s disease
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....adfb70c93e600eff2bfa76b408aad967