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The ubiquitous hammerhead ribozyme
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, RNA, RNA, Cold Spring Harbor Laboratory Press, 2012, 18 (5), pp.871-85. ⟨10.1261/rna.031401.111⟩
- Publication Year :
- 2012
- Publisher :
- Cold Spring Harbor Laboratory, 2012.
-
Abstract
- The hammerhead ribozyme is a small catalytic RNA motif capable of endonucleolytic (self-) cleavage. It is composed of a catalytic core of conserved nucleotides flanked by three helices, two of which form essential tertiary interactions for fast self-scission under physiological conditions. Originally discovered in subviral plant pathogens, its presence in several eukaryotic genomes has been reported since. More recently, this catalytic RNA motif has been shown to reside in a large number of genomes. We review the different approaches in discovering these new hammerhead ribozyme sequences and discuss possible biological functions of the genomic motifs.
- Subjects :
- Hammerhead ribozyme
viruses
Sequence Homology
Review
Cleavage (embryo)
Genome
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: RNA, Catalytic
RNA, Catalytic
MESH: Genome
Nucleotide
MESH: Genetic Variation
MESH: Sequence Homology
Nucleotide Motifs
Molecular Biology
Catalytic RNA
chemistry.chemical_classification
Genetics
biology
fungi
Ribozyme
Genetic Variation
Structure
Catalytic RNAs
biology.organism_classification
Database searches
Homology
MESH: Tandem Repeat Sequences
enzymes and coenzymes (carbohydrates)
MESH: Nucleic Acid Conformation
Retrotransposons
chemistry
Tandem Repeat Sequences
MESH: Nucleotide Motifs
biology.protein
Nucleic Acid Conformation
Mammalian CPEB3 ribozyme
VS ribozyme
Subjects
Details
- ISSN :
- 14699001 and 13558382
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- RNA
- Accession number :
- edsair.doi.dedup.....adef921b5ccaf945d44d62870c348482