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Menopause Does Not Affect Fatty Liver Severity In Women: A Population Study in a Mediterranean Area
- Source :
- Endocrine, Metabolic & Immune Disorders - Drug Targets. 18:513-521
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- Background and objective Estrogens could protect the liver from fatty degeneration, but there is little information about whether menopause is associated with the severity of alcoholic (AFL) and non-alcoholic fatty liver (NAFL). Our aim was to evaluate the distribution of fatty liver detected by ultrasound in pre- and post-menopausal women and the factors associated with these conditions. Methods In this cross-sectional study, the years from menopause were investigated through selfreported information. The degree of fatty liver was assessed through a standardized ultrasound examination (scores 0 to 6, higher values reflecting a greater severity). Liver steatosis was classified as NAFL or AFL based on a daily alcohol intake > 20g/d. Results The study included 752 women in menopause and 535 in pre-menopause. The years from menopause were not associated with the severity of liver steatosis in NAFL (p for trend=0.74; Spearman correlation=0.04; 95%CI: -0.09 to 0.17), whereas all the indexes of adiposity and the number of metabolic syndrome factors were associated with a higher liver steatosis score. Taking AFL liver steatosis as the outcome, the years since menopause were not significantly associated with liver steatosis in AFL (p for trend=0.50; Spearman correlation=0.09; 95%CI: -0.17 to 0.34), whilst the association between anthropometric parameters and liver steatosis severity resulted stronger in postmenopausal compared to pre- menopausal women. Conclusion the higher prevalence of fatty liver observed in post-menopausal women is probably not due to menopause per se, but to the adiposity (particularly abdominal) typical of this age and its consequences (such as metabolic syndrome).
- Subjects :
- Adult
medicine.medical_specialty
Cross-sectional study
Endocrinology, Diabetes and Metabolism
Physiology
030204 cardiovascular system & hematology
Affect (psychology)
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Risk Factors
Severity of illness
Epidemiology
Prevalence
Humans
Immunology and Allergy
Medicine
030212 general & internal medicine
Adiposity
Aged
business.industry
Fatty liver
Middle Aged
Prognosis
medicine.disease
Postmenopause
Menopause
Cross-Sectional Studies
Italy
Liver
Premenopause
Population study
Female
Metabolic syndrome
business
Fatty Liver, Alcoholic
Subjects
Details
- ISSN :
- 18715303
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Endocrine, Metabolic & Immune Disorders - Drug Targets
- Accession number :
- edsair.doi.dedup.....adeeb16eae8b5aebf28732dec8139532