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Fractional Exhaled Nitric Oxide Measurement in Pulmonary Hypertension: A Follow-Up Study
- Source :
- Clinical and Applied Thrombosis/Hemostasis. 24:483-488
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study. Echocardiography, 6-minute walking test, brain natriuretic peptide, and FeNO measurements were performed, and World Health Organization functional class was evaluated to all patients at baseline, and third, and sixth months. Right-heart catheterization and pulmonary function tests at the time of diagnosis were recorded. The study comprised 31 patients (23 women, 8 men; mean age: 53.4 ± 17.1 years) with PAH (n = 19) and CTEPH (n = 12) and 80 healthy controls. Patients with PH had lower FeNO values than the control group (16.5 ppb vs 19.8 ppb; P < .05). Fractional exhaled nitric oxide values did not change during follow-up and did not correlate with other follow-up measures except tricuspid annular plane systolic excursion values. Fractional exhaled nitric oxide was higher in the idiopathic PAH subgroup at baseline and at third month than patients with PAH associated with other diseases. Fractional exhaled nitric oxide did not change in patients who had clinical deterioration. As a conclusion; Patients with PH had lower FeNO values than healthy controls, but FeNO did not change significantly during follow-up. Large-scale studies with prolonged follow-up periods are needed to understand the role of FeNO in the follow-up of the patients with PH.
- Subjects :
- Adult
Male
medicine.medical_specialty
Longitudinal study
Hypertension, Pulmonary
030204 cardiovascular system & hematology
Nitric Oxide
Nitric oxide
Pulmonary function testing
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Thromboembolism
Internal medicine
Humans
Medicine
Outpatient clinic
Longitudinal Studies
Aged
business.industry
Follow up studies
Original Articles
Hematology
General Medicine
Middle Aged
Brain natriuretic peptide
medicine.disease
Pulmonary hypertension
030228 respiratory system
chemistry
Exhalation
Case-Control Studies
Exhaled nitric oxide
Cardiology
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 19382723 and 10760296
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Clinical and Applied Thrombosis/Hemostasis
- Accession number :
- edsair.doi.dedup.....adc396848506f472889e7479feb6cdd2