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Fattiviracin A1, a novel antiviral agent produced by Streptomyces microflavus strain No. 2445. II. Biological properties
- Source :
- The Journal of antibiotics. 51(11)
- Publication Year :
- 1999
-
Abstract
- Fattiviracin A1, showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), influenza A virus and human immunodeficiency virus type 1 (HIV-1). It showed no cytotoxicity against Vero cells. Fattiviracin A1 exhibited no significant antibacterial or antifungal activities. Treatment of HSV-1 with fattiviracin A1 decreased its infectivity to Vero cells. The mechanism of its antiviral activity may be due to inactivation of the viral particles and inhibition of viral entry into host cells.
- Subjects :
- Herpesvirus 3, Human
viruses
Orthomyxoviridae
Herpesvirus 1, Human
Microbial Sensitivity Tests
medicine.disease_cause
Virus Replication
Antiviral Agents
Virus
Microbiology
Viral entry
Drug Discovery
Chlorocebus aethiops
medicine
Influenza A virus
Animals
Vero Cells
Pharmacology
biology
Varicella zoster virus
virus diseases
biology.organism_classification
Virology
Streptomyces
Herpes simplex virus
Glucose
Streptomyces microflavus
Vero cell
Fatty Acids, Unsaturated
HIV-1
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 51
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....adc196651b82816effb4f3318c5a801d