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Development and differentiation of early innate lymphoid progenitors

Authors :: Avinash Bhandoola
Maggie Cam
Jonathan Kaye
Christelle Harly
CHRISTELLE, HARLY
National Institutes of Health [Bethesda] (NIH)
Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA)
Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
National Cancer Institute [Bethesda] (NCI-NIH)
Cedars-Sinai Medical Center
Source :: The Journal of Experimental Medicine, Journal of Experimental Medicine, Journal of Experimental Medicine, 2018, 215 (1), pp.249-262. ⟨10.1084/jem.20170832⟩
Publication Year :: 2017
Publisher :: Rockefeller University Press, 2017.
Abstract: Harly et al. show that early innate lymphoid progenitors (EILPs) are a developmental intermediate between all-lymphoid progenitors (ALPs) and ILC precursors (ILCps) and identify requirements for their generation and further differentiation.<br />Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.