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Immunogenicity of a novel, bivalent, plant-based oral vaccine against hepatitis B and human immunodeficiency viruses
- Source :
- Biotechnology Letters. 28:959-967
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- A synthetic chimeric gene, TBI-HBS, encoding the immunogenic ENV and GAG epitopes of human immunodeficiency virus (HIV-1) and the surface protein antigen (HBsAg) of hepatitis B virus (HBV), was expressed in tomato plants. Tomato fruits containing the TBI-HBS antigen were fed to experimental mice and, on days 14 and 28 post-feeding, high levels of HIV- and HBV-specific antibodies were present in the serum and feces of the test animals. Intraperitoneal injection of a DNA vaccine directing synthesis of the same TBI-HBsAg antigen boosted the antibody response to HIV in the blood serum; however, it had no effect on the high level of antibodies produced to HBV.
- Subjects :
- Hepatitis B virus
HBsAg
Administration, Oral
Bioengineering
Biology
Protein Engineering
medicine.disease_cause
Applied Microbiology and Biotechnology
Epitope
Virus
Microbiology
Blood serum
Solanum lycopersicum
Antigen
medicine
Hepatitis B Vaccines
Plant Extracts
Immunogenicity
virus diseases
General Medicine
Hepatitis B
Plants, Genetically Modified
medicine.disease
Virology
digestive system diseases
Biotechnology
Subjects
Details
- ISSN :
- 15736776 and 01415492
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Biotechnology Letters
- Accession number :
- edsair.doi.dedup.....adae3c1a2bcd9ebfc7057a4ed475a425